This book represents the future of medicine, an individualized, personalized approach that honors our genetic uniqueness. Pamela McDonald brings together a complete health program that honors all we are–body, mind, and spirit.
— Larry Dossey, MD
Author of
The Extraordinary
Healing Power of
Ordinary Things
How many variations are there of the Apo E gene?
There are three Apo E gene variations that occur naturally in humans: Apo E 2, Apo E 3, and Apo E 4. Genes come in matching pairs, so we each have two copies of every gene (one from each parent). There are six possible combinations of Apo E gene pairs or genotypes. If you received an Apo E 2 from one parent and an Apo E 3 from the other parent, the shorthand description of your genotype is E 2/3. The six possible combinations are E 2/2, E 2/3, E 3/3, E 4/2, E 4/3, and E 4/4.
What is the Apo E gene?
Apo is short for apolipoprotein. It has the letter “E” because it’s one of a whole series of apolipoproteins—A, B, C, D, etc. The Apo E gene gets its name from the fact that it’s the blueprint in charge of synthesizing apolipoprotein E, an important component of cholesterol and fat metabolism.
How do you pronounce Apo E?
Apo E is pronounced by saying each letter separately....... A - P - O - E.
Does everyone have an Apo E genotype?
Yes - The question is: which one do you have?
Why is it important to know my Apo E genotype?
Your Apo E genotype greatly affects how your body processes carbohydrates, fats, and proteins, which in turn, affects your weight AND your predisposition toward certain chronic diseases, especially heart disease and Alzheimer's disease.
Once I know my Apo E genotype, can anything be done to reduce my risk of getting these chronic illnesses?
Yes. By adopting a diet and lifestyle that is appropriate for your particular Apo E genotype, you create a "gene-supportive environment (GSE)" for your Apo E genotype. Maintaining this "gene-supportive environment" dramatically reduces your risk of developing chronic diseases such as heart disease and Alzheimer's disease.
Can the Apo E Gene Diet help me lose weight?
Yes. Following the dietary and lifestyle guidelines specific to your particular Apo E genotype enables your body to more efficiently process carbohydrates, fats, and proteins. In essence, the Apo E Gene Diet creates a customized plan for your body to help you lose weight, while at the same time minimizing your risk of developing chronic diseases.
Is the Apo E Gene Diet the same for everyone?
No. That’s what so unique about this diet. There are six Apo E genotypes, and each genotype processes food in a unique way. Accordingly, there are specific optimal diet and exercise guidelines for each of the six Apo E genotypes.
How do I find out what my Apo E gene type is?
Learning your Apo E genotype can be accomplished by performing a cheek swab test or a non-fasting blood test.
Can I get my Apo E gene test at any lab?
No. The Apo E gene test is a specialized test – not all labs perform this test.
Does my Apo E gene test need to be ordered by a medical provider?
Yes. This test needs to be ordered by a licensed medical provider.
Do I need to fast for the Apo E gene test?
No. Fasting is not required because we are only examining genetic material.
What should I consider before making the decision to be tested for my Apo E genotype?
We strongly recommend reading The Perfect Gene Diet by Pamela McDonald before making the decision to be tested. There are many factors to consider regarding gene testing, and this book will guide you through them.
Click here for more information about the Apo E Gene Diet book.
I want to be tested. How do I go about it?
Click here for information on your options for testing.
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Wayne Dyer talks about The Perfect Gene Diet.
About the Author
Pamela McDonald
PNP, FA, WHCNP
Pamela is a leading integrative medicine nurse practitioner, who has devoted her life to the prevention of heart disease and chronic illness by utilizing the body’s own genetic recipe and promoting the use of natural organic whole food.
Pamela was born in Paisley, Scotland, and grew up in the southernmost part of England. She was originally trained at the Royal Hospital of St. Bartholomew’s in London, and then moved to California in 1981.
A nurse practitioner with advanced specialty training in surgery, women’s health care, adult primary care, pediatrics, pediatric obesity, family practice, cardiovascular and heart disease prevention, nutrition, exercise, mind/body medicine, and botanical medicine, Pamela is also educated in allopathic, alternative, and integrative medicine. She is a graduate of the Program in Integrative Medicine at the University of Arizona, founded by Andrew Weil, MD.
Pamela lives just outside San Francisco, CA, with her husband, Rick, and their three children. She maintains a private practice as well as evolving and overseeing her Apo E Gene Diet program. Pamela often lectures to public and private groups.